Folic acid (Folate) should be tested along with Vitamin B12.


Folic acid is necessary for human cell development. Folic acid is closely interrelated with Vitamin B12. Folate and B12 work together to produce S-adenosylmethionine (SAMe).  This compound is involved in immune function and mood.

Lack of Folic Acid leads to an increased risk of cardiovascular disease. There is also a risk of neural tube defects in women of childbearing age.

These risks are attributed to the ability of folic acid to deal with homocysteine in the body.

Deficiency of folic acid or folate may manifest in:

  • Fatigue
  • Grey hair
  • Mouth sores
  • Tongue swelling
  • Growth problems
  • Shortness of breath

Testing for Folate and Vitamin B12 levels is easy and inexpensive.

References: M J Berg, The importance of folic acid, Last accessed 07.06.2021