Lactate Dehydrogenase

High levels of LD usually indicate some type of tissue damage. Usually, LD levels rise as the cells in the body break up. The more cells break up, the higher the LD result.

High levels of LD may be seen with:

  • Anaemias including haemolytic anaemia
  • Pernicious anaemias (megaloblastic anaemia)
  • Infections including infectious mononucleosis (glandular fever), tuberculosis and serious fungal infections
  • Intestinal and lung infarction (tissue death)
  • Liver disease including hepatitis
  • Muscle damage due to trauma or over-exercising
  • Pancreatitis – Inflammation of the pancreas
  • Some cancers including melanoma
  • Cerebrovascular accident (CVA, stroke)
  • Drugs including anaesthetics, narcotics, methotrexate

With some chronic conditions, and some drugs, moderately elevated LD levels.

Low levels of LD do not usually indicate a problem.

Lactate Dehydrogenase is part of the Inflammation test panel.

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